TwistedBrush Pro Studio - A powerful and unique natural media painting program.
Krita - Krita is a professional FREE and open source painting program. It is made by artists that want to seaffordable art tools for everyone. Concept art. texture and matte painters, illustrations and comics.
Adobe Sketch - Adobe Sketch lets users create expressive drawings anywhere using natural drawing tools like pencils, pens, markers and watercolour brushes.
Clip Studio Paint - The artist's software for drawing and painting.
Corel Painter - Corel Painter is media painting software.
MyPaint - MyPaint is a fast, distraction-free, and easy painting tool for digital artists.