Pixel Art Studio - A purpose-built drawing tool for pixel artists
Juice FX - Easily turn your pixel art into VFX for your video game.
Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
PixaTool - Convert any image or video into pixel art 👾
Pixel Art to CSS - Draw and animate pixel art, export the results to CSS
dddraw - A fun little drawing tool to make doodles that have a hand-drawn feel and export them as SVG.