Oregon Trail II VS Galactic Civilizations III: Crusade

Sins Of A Solar Empire - Sins of a Solar Empire is an Adventure, Strategy, Real-time-strategy, Science-fiction, Exploration, Aliens, Single and Multiplayer Space Simulation developed by Ironclad Games and published by Stardock.

Battlefleet Gothic: Armada - Battlefleet Gothic: Armada is a Real-time Strategy, Sci-Fi, Single and Multiplayer video game developed by Tindalos Interactive and published by Focus Home Interactive.

Space Station 13 - Space Station 13 is a Ton-Down, Role-playing, Space and Multiplayer video game set on a futuristic space station where the player can choose to play from a selection of different jobs.

Homeworld - Homeworld is an Action-Adventure, Science-fiction, Real-time Strategy, Real-time-tactical, Single and Multiplayer Space Simulation created by Relic Entertainment and published by Sierra Entertainment.

Endless Space - Endless Space is an Amazing, Strategy, Science-fiction, Turn-based, Space, Futuristic, Exploration, Co-op, Single and Multiplayer Space Simulation created and published by Amplitude Studios.

EVE Online - Player-created empires, player-driven markets, and endless ways to embark on your personal sci-fi adventure.