LibreCAD - An open source 2D CAD application for Windows, Apple and Linux.
LinuxCNC (the Enhanced Machine Control) - LinuxCNC: an open source CNC machine controller. It can drive milling machines, lathes, 3d printers, laser cutters, plasma cutters, robot arms, hexapods, and more.
FreeCAD - An open-source parametric 3D modeler
Mach3 - Mach3 is very popular among the Hobby CNC community.
gCAD3D - 3D - CADCAM - Software for MS-Windows and Linux. Freeware
PyCAM - PyCAM is a toolpath generator for 3-axis CNC machining.