PySimpleGUI - A simple to use GUI that can create custom GUIs
PyQt - Riverbank | Software | PyQt | What is PyQt?
Tkinter - Tkinter is a Python wrapper for Tcl/Tk that offers classes to create various graphical user interfaces.
GTK - GTK+ is a multi-platform toolkit for creating graphical user interfaces.
PyGObject - PyGObject is a python extension module that allows Python programs to easily interface and make use of libraries using the GObject type system.
wxWidgets - wxWidgets: Cross-Platform GUI Library