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LDraw - LDraw is an open standard for LEGO CAD programs that allow the user to create virtual LEGO models...
Stud.io - Build LEGO designs online with friends.
LDCad - LDCad is a multiplatform ...
Mecabricks.com - Mecabricks is an online LEGO building tool.
MLCAD - MLCad LEGO Cad Software
Bricksmith - Bricksmith allows you to create virtual instructions for your Lego creations on your Mac.