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Refined Twitter - A browser extension that improves the Twitter experience
Facebook friends feed - Facebook with stories only by friends and pages you follow
Tweetbot - Sync your timeline across your iPhone, iPad, and Mac. Mute tweets by user, hashtag, tweet source, or keywords (including regex). 3rd Party support for image, video, read later, and timeline sync services.
Detox for Facebook - Replace your Facebook feed with PH, HN, DN and more.
ilo - Premium Twitter analytics
Keep My Friends - A lightweight, personal CRM to improve your relationships