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libtwo - All-purpose c++ app prototyping library, focused towards live graphical apps and games
Unity - The multiplatform game creation tools for everyone.
Pygame - Pygame is a set of Python modules designed for writing games.
Godot Engine - Feature-packed 2D and 3D open source game engine.
Unigine - Unigine Engine is a proprietary cross-platform middleware, developed by Unigine Corp.
Blender - Blender is the open source, cross platform suite of tools for 3D creation.