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VTube Studio - VTube Studio is an app for Virtual YouTubers that makes VTubing easy and fun!!
Spine - Spine is 2D animation software designed specifically for software and game development.
VSeeFace - VSeeFace is a free, highly configurable face and hand tracking VRM and VSFAvatar avatar puppeteering program for virtual youtubers with a focus on robust tracking and high image quality
Synfig Studio - Just another WordPress site
MakeHuman - MakeHuman is a free, open source, interactive modeling tool for creating custom 3D human characters.
AnimeEffects - AnimeEffects is a 2D keyframe animation tool based on deformation of polygon meshes.