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Spine - Spine is 2D animation software designed specifically for software and game development.
Synfig Studio - Just another WordPress site
Blender - Blender is the open source, cross platform suite of tools for 3D creation.
AnimeEffects - AnimeEffects is a 2D keyframe animation tool based on deformation of polygon meshes.
Grafx2 - GrafX2 is a bitmap paint program inspired by the Amiga programs Deluxe Paint and Brilliance.
DragonBones - DragonBones is an open source project for 2D skeletal animation.