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WeeChat - WeeChat is a fast, light and extensible chat client.
ZNC - znc is an IRC proxy. It runs as a daemon and connects to IRC server, then allows you to connect...
Kiwi IRC - A hand-crafted IRC client that you can enjoy. Designed to be used easily and freely.
The Lounge - The Lounge is a web IRC client that you host on your own server.
mIRC - mIRC: Internet Relay Chat client
Quassel IRC - Quassel IRC is a modern, cross-platform, distributed IRC client based on the Qt4 framework.