Girder - Made by Promixis, Girder is the award winning home and industrial automation software that allows...
Home-Assistant.io - Home Assistant is an open-source home automation platform running on Python 3.
ioBroker - flexible and modular application for the IoT and Smarthome
openHAB - "empowering the smart home" - vendor and technology agnostic open source home automation
Home - Securely control all your HomeKit accessories from your favorite iOS device.
EventGhost - EventGhost is an advanced, easy to use and extensible automation tool for MS Windows.