Girder - Made by Promixis, Girder is the award winning home and industrial automation software that allows...
FHEM - FHEM (TM) is a GPL'd perl server for house automation.
Home-Assistant.io - Home Assistant is an open-source home automation platform running on Python 3.
Conrad Connect - Service for managing smart home devices
openHAB - "empowering the smart home" - vendor and technology agnostic open source home automation
ioBroker - flexible and modular application for the IoT and Smarthome