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TweetDeck - TweetDeck is your personal browser for staying in touch with what’s happening now.
Tweetium - Tweetium is first and foremost designed to be quick and reliable.
Tweetbot - Sync your timeline across your iPhone, iPad, and Mac. Mute tweets by user, hashtag, tweet source, or keywords (including regex). 3rd Party support for image, video, read later, and timeline sync services.
HootSuite - Enhance your social media management with Hootsuite, the leading social media dashboard. Manage multiple networks and profiles and measure your campaign results.
Socialite - History Ever since we acquired Socialite from Realmac Software in December 2010, we have been planning on releasing a faster, more stable version 2.
TweetDuck - Free & open source desktop client for TweetDeck