TweetDeck - TweetDeck is your personal browser for staying in touch with what’s happening now.
Tweetbot - Sync your timeline across your iPhone, iPad, and Mac. Mute tweets by user, hashtag, tweet source, or keywords (including regex). 3rd Party support for image, video, read later, and timeline sync services.
Twitterfall - Twitterfall is an excellent choice if you want something basic, free and without much branding.
Socialite - History Ever since we acquired Socialite from Realmac Software in December 2010, we have been planning on releasing a faster, more stable version 2.
Tweetdeckr - Tweetdeckr is an open source Tweetdeck replacement client.
Choqok - Choqok - KDE Micro-Blogging Client The name comes from an ancient Persian word, means Sparrow!