Home-Assistant.io - Home Assistant is an open-source home automation platform running on Python 3.
ioBroker - flexible and modular application for the IoT and Smarthome
Domoticz - Domoticz is a lightweight Home Automation System
openHAB - "empowering the smart home" - vendor and technology agnostic open source home automation
SEQUEmatic - SEQUEmatic lets you build sequences to link together your various smart devices.
Home - Securely control all your HomeKit accessories from your favorite iOS device.