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ChemDraw - ChemDraw - The Gold Standard for Chemical Structure Drawing and Research Publications.
Avogadro - Avogadro is a free, fantastically easy to use molecule editor.
ChemDoodle - Chemical drawing and publishing software for desktop, web and mobile. Affordable and used by thousands of scientists around the world. Free trial available for immediate download.
BKchem - BKChem is a free (as in free software :o) chemical drawing program.
Ptable - Interactive periodic table with dynamic layouts showing names, electrons, oxidation, trend visualization, orbitals, isotopes, and compound search. Full descriptions from write-up sources.
MolView - Open Source online service