EventGhost - EventGhost is an advanced, easy to use and extensible automation tool for MS Windows.
Home-Assistant.io - Home Assistant is an open-source home automation platform running on Python 3.
openHAB - "empowering the smart home" - vendor and technology agnostic open source home automation
LIRC - LIRC - linux infrared remote control
ioBroker - flexible and modular application for the IoT and Smarthome
WinLIRC - WinLIRC allows you to transmit and receive standard infrared remote control signals.