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ns-3 - a discrete-event network simulator for internet systems
AnyLogic - AnyLogic has changed simulation modeling and expanded its application into complex business environments. The unmatched flexibility of multimethod modeling allows users to capture the complexity of virtually any system, at any level of detail.
Paessler Multi Server Simulator - Paessler Multi Server Simulator is inexpensive and robust software that helps you power massive-scale testing.
FlexSim - Simulation software to model, simulate, predict, and visualize systems in manufacturing, material handling, healthcare, warehousing, mining, etc.
Simio - Facility design simulation & production scheduling
GNS3 - GNS3 is a graphical network simulator that allows simulation of complex networks.