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ZynAddSubFX - ZynAddSubFX is an open source software synthesizer for Linux, Mac OS X and Microsoft Windows.
Voxal - Modify your voice in any application that uses a microphone. From girl to alien, the voice options for online video games, avatars and podcasts are limitless.
Surge XT - Open-source subtractive-hybrid synthesizer formerly sold commercially as Vember Audio Surge.
Autotalent - To make music
Qsynth - Qsynth is a simple Qt4 application wrapper for the ...
FL Studio - Image-Line's FL Studio, now on it's 12th version, is a well-known music production suite and the most popular beat processor on the market, due no doubt to its longevity. Read more about FL Studio.