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Pidgin - Pidgin is an easy to use and free chat client used by millions. Connect to AIM, MSN, Yahoo, and more chat networks all at once.
Trillian - Trillian is a decentralized and federated instant messaging platform that lets your whole company send private and group messages, keep tabs on what co-workers are doing, share files, and much more.
Miranda IM - Miranda IM is the smaller, faster, easier instant messenger with support for multiple protocols.
Skype - Stay in touch with your family and friends for free on Skype. Download Skype today to chat and call on desktop and mobile.
Gajim - Full featured and easy to use Jabber client
Adium - Adium is a free instant messaging application for Mac OS X that can connect to AIM, MSN, Jabber, Yahoo, and more.