Mach3 - Mach3 is very popular among the Hobby CNC community.
Unity - The multiplatform game creation tools for everyone.
LinuxCNC (the Enhanced Machine Control) - LinuxCNC: an open source CNC machine controller. It can drive milling machines, lathes, 3d printers, laser cutters, plasma cutters, robot arms, hexapods, and more.
Godot Engine - Feature-packed 2D and 3D open source game engine.
SolidCAM - The ‘Best-in-Class’ CAM Solution for Efficient & Profitable CNC-Programming Inside Your CAD
Blender - Blender is the open source, cross platform suite of tools for 3D creation.