LinuxCNC (the Enhanced Machine Control) - LinuxCNC: an open source CNC machine controller. It can drive milling machines, lathes, 3d printers, laser cutters, plasma cutters, robot arms, hexapods, and more.
Autodesk Fusion 360 - Integrated CAD, CAM, and CAE featuring collaborative editing and cloud-based computation.
Mach3 - Mach3 is very popular among the Hobby CNC community.
Solid Edge - Solid Edge is an industry-leading mechanical design system with exceptional tools for creating and...
PyCAM - PyCAM is a toolpath generator for 3-axis CNC machining.
MATLAB - A high-level language and interactive environment for numerical computation, visualization, and programming