LinuxCNC (the Enhanced Machine Control) - LinuxCNC: an open source CNC machine controller. It can drive milling machines, lathes, 3d printers, laser cutters, plasma cutters, robot arms, hexapods, and more.
Ink/Stitch - An Inkscape extension for designing machine embroidery patterns.
Mach3 - Mach3 is very popular among the Hobby CNC community.
Embird - Machine-Independent Embroidery Software
PyCAM - PyCAM is a toolpath generator for 3-axis CNC machining.
Wilcom TrueSizer - Based on the same core software as Wilcom’s acclaimed professional embroidery design software, .