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AnimeEffects - AnimeEffects is a 2D keyframe animation tool based on deformation of polygon meshes.
Spine - Spine is 2D animation software designed specifically for software and game development.
Synfig Studio - Just another WordPress site
DragonBones - DragonBones is an open source project for 2D skeletal animation.
Creature - Creature 2D Skeletal and Mesh Animation Tool
Adobe Animate - Adobe Animate is a Flash, vector animation software.