With a strong focus on natural media painting, photo editing and illustrative styles, TwistedBrush has more than 9000 brushes in over 250 ArtSets! That's more brushes than included in any art software anywhere at any price. If that still isn't enough you can create your own brushes with the powerful brush effects system capable of representing fine watercolors, smooth pens, full algorithmic trees or even recorded brush strokes or image processing filters.
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Sirius - An open-source clone of Siri from UMICH
Krita - Krita is a professional FREE and open source painting program. It is made by artists that want to seaffordable art tools for everyone. Concept art. texture and matte painters, illustrations and comics.
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Artrage - A simple but lovely natural media painting and sketching program.