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Element.io - Secure messaging app with strong end-to-end encryption, advanced group chat privacy settings, secure video calls for teams, encrypted communication using Matrix open network. Riot.im is now Element.
Hermes - Pandora Client for OS X
ChatSecure - ChatSecure is a free and open source messaging app that features OTR encryption over XMPP.
Pithos - pithos is a daemon which provides an S3-compatible frontend for storing files in a Cassandra cluster.
Keybase Chat - End-to-end encrypted chat built into Keybase
M for iOS - Email app with automatic encryption