Pixel Art Studio - A purpose-built drawing tool for pixel artists
PICO-8 - Lua-based fantasy console for making and playing tiny, computer games and programs.
Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
TIC-80 - TIC-80 is a fantasy computer where you can make, play and share tiny games.
Pixel Studio - The Pixel Art Is Always Fun
LIKO-12 - Fantasy console built with the Love 2D game engine.