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Spine - Spine is 2D animation software designed specifically for software and game development.
Unity 2D - Unity 2D is a powerful and feature-rich game design solution built from the ground up to fulfill every basic and advanced need of the developer.
Synfig Studio - Just another WordPress site
Live2D Cubism - Live2D is the world's first drawing technology to enable 3D rendering of 2D images.
CrazyTalk Animator - CrazyTalk Animator, the next level of 2D animation. Create actors using any photo or illustration.
DragonBones - DragonBones is an open source project for 2D skeletal animation.