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Gwibber - Gwibber is an open source microblogging client for GNOME developed with Python and GTK.
Janetter - Janetter is a Twitter client application. Faster, smarter, and more powerful.
TweetDeck - TweetDeck is your personal browser for staying in touch with what’s happening now.
YoruFukurou - YoruFukurou (NightOwl) is a Twitter client for Mac OS X, designed for Twitter addicts.
Tweetbot - Sync your timeline across your iPhone, iPad, and Mac. Mute tweets by user, hashtag, tweet source, or keywords (including regex). 3rd Party support for image, video, read later, and timeline sync services.
Tweeticide - Tweeticide – Delete All Tweets is a commercial app that enables you to delete all of your tweets at once.