Plenty of older games only seem to work with certain versions of Proton/Wine, DXVK etc. There are projects like Bottles which let you manage multiple Proton distributions https://usebottles.com/. - Source: Hacker News / 18 days ago

If it need installation (or has some kind of wizard), probably look into UseBottles and once installed, link the .exe to Steam. Source: 6 months ago

Bottles is very convenient to manage wine https://usebottles.com/. Source: 6 months ago

For "normal" games you could look yourself using ProtonDB regarding every game released on Steam and AreWeAntiCheatYet for most multiplayer games. If a game isn't available on Steam you have three possibilities. First if it's available on GOG, Epic Games or Amazon Gaming, you could use the Heroic Games Launcher. Second you could try to run the launchers through Steam itself using once again Proton. Third you... Source: 6 months ago

Bottles is great for old classic non-steam games. I haven't tried 🏴‍☠️ with it but I can't see why it wouldn't work. Source: 6 months ago

Try to remove the emulator in Configure emulators,and import it again, it could work. You can also try different emulators like Nestopia or FCEUX (the one I am personally using). Source: about 2 years ago