Gemini Lost - Gemini Lost is an Action, Strategy, Single-player and life-Simulation created and published by PlayFirst.
MySims Kingdom - MySims Kingdom is based upon The Sims series but provides special and extremely different gameplay to the original series making it definitely worth your consideration.
Stardew Valley - Stardew Valley is a 2D Awesome, Action, Role-playing, Crafting, Top-down, Building, Sandbox and Single-player video game create by ConcernedApe and published by Chucklefish.
Gleamville - Gleamville is a Free, MMORPG, Browser-based, Social Networking, Fantasy and Virtual World Simulation.
Dream Builder: Amusement Park - Dream Builder: Amusement Park is a Commercial, City-Building, Strategy, and Simulation created by Big Fish Games.
Virtual Villagers - Virtual Villagers collection is a selection of life simulation games.