Blender - Blender is the open source, cross platform suite of tools for 3D creation.
Mastercam - Mastercam's Dynamic Milling is a game changer for us.
FreeCAD - An open-source parametric 3D modeler
Vectric Aspire - The complete software solution for CNC Routing,
MATLAB - A high-level language and interactive environment for numerical computation, visualization, and programming
Mach3 - Mach3 is very popular among the Hobby CNC community.