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LibreCAD - An open source 2D CAD application for Windows, Apple and Linux.
Blender - Blender is the open source, cross platform suite of tools for 3D creation.
SketchUp - 3D for Everyone
MakeHuman - MakeHuman is a free, open source, interactive modeling tool for creating custom 3D human characters.
FreeCAD - An open-source parametric 3D modeler
Bforartists - Bforartists is a fork of Blender.