Blender - Blender is the open source, cross platform suite of tools for 3D creation.
JugiPaint - JugiPaint is a painting software with diverse tools for various types of illustration work.
Cinema 4D - Cinema 4D is a 3D modeling, animation, motion graphics and rendering application.
miniPaint - Online graphics editing tool use HTML5 technologies like Canvas, Offline support, Drag and Drop.
Autodesk Maya - Maya is 3D computer animation software with powerful modeling, rendering, simulation, texturing, and animation tools for artists, modelers, and animators.
RealWorld Paint - RealWorld Paint is an free portable image/photo/animation editor.