PICO-8 - Lua-based fantasy console for making and playing tiny, computer games and programs.
Blender - Blender is the open source, cross platform suite of tools for 3D creation.
Moai - Moai is a spiritual successor to one of the elder gods of pixel editing: Autodesk Animator.
Autodesk 3DS Max - 3ds Max is software for 3D modeling, animation, rendering, and visualization. Create stunning game enrivonments, design visualizations, and virtual reality experiences.
GnuPG - GnuPG is a complete and free implementation of the OpenPGP standard as defined by RFC4880 (also known as PGP).
ZBrush - ZBrush is a digital sculpting and painting software solution.