Sketch - Professional digital design for Mac.
Spine - Spine is 2D animation software designed specifically for software and game development.
Inkscape - Inkscape is a free, open source professional vector graphics editor for Windows, Mac OS X and Linux.
CrazyTalk Animator - CrazyTalk Animator, the next level of 2D animation. Create actors using any photo or illustration.
Affinity Designer - Professional creative software, exclusively for Mac.
Synfig Studio - Just another WordPress site