Inkscape - Inkscape is a free, open source professional vector graphics editor for Windows, Mac OS X and Linux.
VideoScribe - Make your own whiteboard video animations with Sparkol VideoScribe – award-winning video scribing app for PC, Mac and iPad. Free trial available.
Blender - Blender is the open source, cross platform suite of tools for 3D creation.
GoAnimate - Make your own animation quickly and economically with GoAnimate. Reach prospects and customers with animated videos online about your business and products.
Sculptris - Sculptris: Enter a world of digital art without barriers.
Cinema 4D - Cinema 4D is a 3D modeling, animation, motion graphics and rendering application.