MirrorCreator - Upload one file of 400 megs or less to multiple free file hosts -- 14 at most. 25 possible hosts.
Loadpass - Start Uploading Your Files To Multiple File Hosting Sites
DirectMirror - Directmirror.com uploads your file to several free hosting providers.
Files to Friends - Files to Friends is a file-sharing service that makes it easy for you to share files with anyone.
MultiUp - Your files will be uploaded on many filehosting websites. MultiUp.org is a file mirror website.
Mirrors Up - Mirrors Up helps you upload files to your own accounts on multiple hosting sites!