Tkinter Alternatives

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A simple to use GUI that can create custom GUIs

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A drag and drop GUI Designer that uses a combination of Tkinter and its own code.

Dear PyGui is a simple to use (but powerful) Python GUI framework. Dear PyGui provides a wrapping of Dear ImGui which simulates a traditional retained mode GUI (as opposed to Dear ImGui's immediate mode paradigm).

Open Source

Open source Python framework for rapid development of applications that make use of innovative user interfaces, such as multi-touch apps. Installation on WindowsInstallation on Windows. Installation; What are wheels .

Open Source

GTK+ is a multi-platform toolkit for creating graphical user interfaces.

Open Source

Write your apps in Python and release them on iOS, Android, Windows, MacOS, Linux, Web, and tvOS...

wxPython is a GUI toolkit for the Python programming language.

Open Source

wxWidgets: Cross-Platform GUI Library

Open Source

PyGObject is a python extension module that allows Python programs to easily interface and make use of libraries using the GObject type system.

PyGTK lets you to easily create programs with a graphical user interface using the Python...

Qt for Python - Qt Wiki

WompMobile offers tow kind of functions – first creating new mobile apps and secondly converting the websites into mobile applications.