Not too far ago, I invested several days into "mastering" and tuning TiddlyWiki. It was an interesting experience. I loved it on the whole and felt very enthusiastic about using it store all my knowledge. It's super flexible and use of tags, filters and macros make it unique. However, it's a bit complicated for mass adoption. Also, the extended use of its powerful features may make your computer tangibly slow.
That's why I found "Obsidian", that's what I'm using today to store my knowledge.