I created a few nice looking websites with the free version of RocketCake - it it very easy to use and simply gets out of the way. It has all the options I need and you can create complicated stuff with mostly a few clicks.
PyQt - Riverbank | Software | PyQt | What is PyQt?
Webflow - Build dynamic, responsive websites in your browser. Launch with a click. Or export your squeaky-clean code to host wherever you'd like. Discover the professional website builder made for designers.
Kivy - Open source Python framework for rapid development of applications that make use of innovative user interfaces, such as multi-touch apps. Installation on WindowsInstallation on Windows. Installation; What are wheels .
WiX - Create a free website with Wix.com. Customize with Wix' website builder, no coding skills needed. Choose a design, begin customizing and be online today
Tkinter - Tkinter is a Python wrapper for Tcl/Tk that offers classes to create various graphical user interfaces.
Grapedrop - Build free, responsive, website pages with an easy to use online builder. Design and publish online immediately or export the code and host it wherever you want