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GNU Octave - GNU Octave is a programming language for scientific computing.
MATLAB - A high-level language and interactive environment for numerical computation, visualization, and programming
Wolfram Mathematica - Mathematica has characterized the cutting edge in specialized processing—and gave the chief calculation environment to a large number of pioneers, instructors, understudies, and others around the globe.
Maxima - Maxima is a fairly complete computer algebra system written in Lisp with an emphasis on symbolic computation.
PTC Mathcad - PTC Mathcad PTC Mathcad is Engineering Math Software That Allows You to Perform, Analyze, and Share Your Most Vital Calculations.
Sage Math - Sage is a free open-source mathematics software system licensed under the GPL.