TweetDeck - TweetDeck is your personal browser for staying in touch with what’s happening now.
HootSuite - Enhance your social media management with Hootsuite, the leading social media dashboard. Manage multiple networks and profiles and measure your campaign results.
Gwibber - Gwibber is an open source microblogging client for GNOME developed with Python and GTK.
Tweetbot - Sync your timeline across your iPhone, iPad, and Mac. Mute tweets by user, hashtag, tweet source, or keywords (including regex). 3rd Party support for image, video, read later, and timeline sync services.
Seesmic - Seesmic was a suite of freeware web, mobile, and desktop applications which allowed users to simultaneously manage user accounts for multiple social networks, such as Facebook and Twitter.
SproutSocial - Sprout Social is a social media management tool created to help businesses find new customers & grow their social media presence. Try it for free.