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irssi - Irssi is a terminal based IRC client for UNIX systems.
WeeChat - WeeChat is a fast, light and extensible chat client.
HexChat - HexChat is a fork of XChat with bug fixes and new features.
KVIrc - KVIrc is a free portable IRC client based on the excellent Qt GUI toolkit.
Adium - Adium is a free instant messaging application for Mac OS X that can connect to AIM, MSN, Jabber, Yahoo, and more.
mIRC - mIRC: Internet Relay Chat client