OpenTTD - An open-source clone of the classic game ...
Transport Fever - Transport Fever is an Adventure-based, Management, Strategy, Economy, Sandbox, City-Building and Single-player video game developed by Urban Games and published by Gambitious Digital Entertainment.
Simutrans - Simutrans is an open-source transport simulator.
Transport Tycoon Deluxe - Transport Tycoon Deluxe is a Business Simulation developed by Chris Sawyer and published by MicroProse.
Rail Nation - Become a logistics tycoon in this fascinating railroad strategy game.
Mashinky - A great railroad tycoon game in active development.