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Inkscape - Inkscape is a free, open source professional vector graphics editor for Windows, Mac OS X and Linux.
Sencha Animator - I just learned about the halt to production and development of Sencha Animator.
Blender - Blender is the open source, cross platform suite of tools for 3D creation.
GSAP - GSAP (GreenSock Animation Platform) is a suite of JavaScript tools for high-performance animations that work in all major browsers.
Cinema 4D - Cinema 4D is a 3D modeling, animation, motion graphics and rendering application.