OpenTTD - An open-source clone of the classic game ...
ANNO - ANNO is a city-building and economic simulation video game series, with real-time strategy elements.
Citybound - Open-source city building sim with a focus on realism through microscopic details
Tropico - Tropico is an Addictive, Strategy, Construction and Management, City Building, Sandbox and Single-player Simulation developed by PopTop Software.
Cities: Skylines - Cities: Skylines is a Construction and Management, City Building, and Single-player Simulation developed by Colossal Order and published by Paradox Interactive.
TheoTown - A City simulation game with great nostalgic graphics.