Vectric Aspire - The complete software solution for CNC Routing,
Autodesk Fusion 360 - Integrated CAD, CAM, and CAE featuring collaborative editing and cloud-based computation.
Autodesk ArtCAM - ArtCAM is a cad/cam software program thats been designed for artisans instead of engineers.
PyCAM - PyCAM is a toolpath generator for 3-axis CNC machining.
SprutCAM - SprutCAM all-in-one software for CNC machines programming
Mach3 - Mach3 is very popular among the Hobby CNC community.