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Spine - Spine is 2D animation software designed specifically for software and game development.
Synfig Studio - Just another WordPress site
AnimeEffects - AnimeEffects is a 2D keyframe animation tool based on deformation of polygon meshes.
Animation Paper - Animation Paper is a software package for doing 2D animation.
DragonBones - DragonBones is an open source project for 2D skeletal animation.
DigiCel FlipBook - Whether you do 2D, 3D or stop motion Animation, DigiCel FlipBook makes animation easier!